丙型肝炎患者血清瘦素水平和外周血B细胞、T细胞亚群水平与肝功能损伤的相关研究

目的：探讨了血清瘦素水：平和外周胞B细胞、T细胞亚群在丙型肝炎病毒感染造成肝功能损伤过程中的作用。方法：采用放射免疫分析和单克隆抗体法对65例丙型肝炎患者进行了血清瘦素和外周血B细胞、T细胞亚群与肝功能相关的生化指标进行检测，并与35名正常健康人作比较。结果：丙型肝炎患者瘦索、B细胞数均非常显著地高于正常人组（P〈0．01），而CD3、CIM、CIM／CD8则显著地低于正常人组（P〈0．01），且与ALT、TBil水平呈明显的正相关。结论：检测丙型肝炎患者血清瘦素水平以及外周血B细胞和T细胞亚群水平的变化在一定程度上反映了机体的免疫功能状态和肝脏的受损程度，具有一定的临床实用价值。

Study on the Changes of Serum Leptin Level, Peripheral B cell Number, T cell Subsets Distribution type in Patients with Hepatitis C and the Relationship Between the Changes and Liver Dysfunction

Objective To investigate the changes of serum leptin level,B cell number,T-cell subsets in patients with hepatitis C and the relationship between the changes and liver function alterations.Methods Serum leptin levels(with RIA),peripheral B cell number,T cell subsets distribution type(with monoclonal antibody technique),ALT and total bilirubin(with biochemistry)were measured in 65 patients with hepatitis C and 35 controls.Results The serum leptin level and B cell percentage in the patients were significantly higher than those in controls(P<0.01),while the CD3,CD4 percentage and CD4/CD8 ratio were significantly lower(P<0.01).The serum leptin levels were significantly positively correlated with those of ALT and total bilirubin(P<0.01).Conclusion Serum leptin levels correlated well with those of two major liver function indicators(ALT and total bilirubin),thus,leptin might be used as a part of liver function test battery.Changes in B and T cell subsets demonstrated immuno-disturbances in patients with hepatitis C.