硬膜外阻滞辅以咪达唑仑对术中遗忘作用的观察

目的: 观察硬膜外阻滞辅以咪达唑仑对术中遗忘发生的影响。方法: 选择ASAⅠ~Ⅱ级择期手术患者38例,均采用硬膜外阻滞,随机分成咪达唑仑组(A组,n=19)和氟哌利多(B组,n=19),待麻醉平面出现满意后,经莫菲滴管给药,A组给咪达唑仑3 mg+哌替啶50 mg,B组给氟哌利多2.5 mg+哌替啶50 mg。观察术后24 h遗忘情况。结果: 咪达唑仑组部分遗忘3例,完全遗忘15例,遗忘率达95.0%;氟哌利多组部分遗忘3例,完全遗忘1例,遗忘率21.1%。两组差异有统计学意义(P<0.001)。结论: 硬膜外阻滞辅以咪达唑仑有较好的术中遗忘作用。

Amnesia effect of midazolam used as an adjuvant during epidural blockade

Objective: To compare the amnesia effect of midazolam and droperidol used as an adjuvant during epidural blockade in surgical patients.Methods: Thirty-eight patients(ASA Ⅰ-Ⅱ)were randomly divided into midazolam groups and droperido group(19 cases in each).After epidural blockade was established,midazolam 3 mg and meperiding 50 mg were infused to the midazolam group(group A),while droperidol2.5 mg and meperiding 50 mg were infused to the droperido group(group B).The amnesia effect was observed in both groups during 24 hours after operation.Results: The rate of amnesia reached 95.0% in group A,but only 21.1% in group B;the difference was significant(P<0.001).Conclusions: Midazolam used as adjuvant during epdural blockade has a better amnesia effect.