氟哌啶醇对慢性精神分裂症患者泌乳素的影响

目的：探讨氟哌啶醇对泌乳素的影响及其与临床疗效的关系。方法：采用固定剂量氟哌啶醇治疗慢性精神分裂症４５例，疗程１２周，在治疗前后评定阳性与阴性症状量表（ＰＡＮＳＳ），并用放射免疫法测查血浆中泌乳素（ＰＲＬ）浓度。

The effect of haloperidol on prolactin in chronic schizophrenia

Objective: To examine the effect of haloperidol on plasma prolactin level and its relationship with clinical response. Method: Fortyfive patients with diagnosis of chronic schizophrenia were treated with a fixed dose of haloperidol for 12 weeks. The subjects were assessed with the PANSS scale before and after treatment. Plasma prolactin level was measured with radioimmune assay. Normal subjects were recruited as control for comparison of baseline prolactin level. Results: There were significant decrease in the PANSS total score, P,N & G subscore after treatment. The baseline prolactin level was significantly higher in patients than control. The prolactin level in patient group increased significantly after treatment and the increase was positively correlated with the reduction in the P subscore. The prolactin level was also significantly higher in female than male patients after treatment. Conclusion: The increase in plasma prolactin induced by neuroleptics could be sensitive biological marker to predict therapeutic response.