静电纺丝纳米纤维组织工程支架的研究进展

背景：静电纺丝纳米纤维具有促进细胞生长的作用。目的：描述静电纺纳米支架对细胞生长的促进作用以及静电纺纳米支架孔径大小、机械强度缺陷改进的研究进展。方法：检索数据库为CNKI数字图书馆全文、PubMed数据库2001至2011年有关静电纺丝和组织工程支架的文献。检索关键词为“组织工程,静电纺丝,支架;electrospinning,tissue engineering scaffolds,nanofiber”。结果与结论：静电纺丝纳米纤维直径、孔径大小及纤维表面对细胞生长行为有重要影响,小孔径静电纺丝纳米纤维支架不利于细胞浸润生长,且用单一电纺技术制备得到的纳米纤维支架机械性能较差,如何增加静电纺丝纳米纤维支架孔径大小以提高细胞的浸润以及提高其机械性能强度,是目前应用研究应解决的问题。

Progress of electrospun nanofiber scaffolds for tissue engineering

BACKGROUND： Electrospun nanofiber scaffolds can promote the cell growth OBJECTIVE： To describe the effect of electrospun nanofiber scaffolds on the cell growth behavior, and to explore the improvement in the pore size and mechanical strength of electrospun nanofiber scaffolds. METHODS： The databases of CNKI and PubMed were searched with the key words of ＂electrospinning, tissue engineering scaffolds, nanofiber＂ in Chinese and English from 2001 to 2011 to retrieve literature related to electrospinning and tissue engineering scaffolds. RESULTS AND CONCLUSION： Cell growth behavior is influenced by the properties of electrospun nanofibrous scaffolds, such as fiber diameter, pore size and fiber surface modification. However, inherently small pores of electrospun nanofiber scaffolds do not promote adequate cellular infiltration and tissue growth. Electrospun nanofiber scaffolds have poor mechanical properties. How to increase the pore size of electrospun nanofiber scaffolds to improve cellular infiltration and promote the mechanical strength is an issue for applied research to be addressed.