修补腹壁疝片对内源性组织再生及缺损组织的修复效应

背景：目前,临床上应用的补片主要是人工合成材料,会不同程度引起一些并发症。目的：详细综合分析目前腹壁疝补片的研究进展,探索其未来发展方向。方法：应用计算机检索Elsevier数据库和中国期刊全文数据库中关于补片方面的文章,在标题和摘要中以“腹壁疝,补片,聚丙烯,聚四氟乙烯,复合补片”或“hernia,patch,polypropylene,compound patch”为检索词进行检索。选择与补片类型、生物相容性和临床应用相关的文献。结果与结论：聚丙烯补片会与腹腔内组织产生严重粘连、消化道梗阻甚至肠瘘。膨化聚四氟乙烯补片修补后的牢固性和抗感染能力较差。聚羟基乙酸网、聚乳酸羟基乙酸网等可吸收材料具有较好的抗感染能力,可促进胶原增殖。聚丙烯和膨化聚四氟乙烯及与可吸收材料相结合的复合型疝修补材料既能使组织很好长入,又能防止与内脏粘连,但植入后会引起局部组织炎症及感染。进一步研发性能优异、具有仿生细胞外基质的三维框架结构、能够通过内源性组织再生对缺损组织进行修补的补片成为补片领域的一个重要发展方向。

Effect of ventral hernia patch on endogenous tissue regeneration and tissue defect repair

BACKGROUND： At present, the hernia patch is mainly made of artificial biomaterials, which will arise some complications in a certain extent. OBJECTIVE： To review the recent studies and progress of hernia patch, and to explore its developing direction. METHODS： The databases of Elsevier and CNKI were retrieved by computer with key words of ＂hernia, patch, polypropylene, expanded polytetrafluoroethylene, compound patch＂ in English and Chinese, respectively. Articles regarding patch classification, biocompatibility and application effects were included. RESULTS AND CONCLUSION： Polypropylene mesh will conglutinate with tissues in the abdominal cavity, resulting in alimentary canal blocking and intestines fistula. Expanded polytetrafluoroethylene patch with poor reliability and anti-infection ability must be removed as soon as the tissues are infected. Absorbable materials such as polyglycolic acid and polyglaction with perfect anti-infection ability can accelerate the collagen multiplication. The composite patches of polypropylene with expanded pelytetrafluoroethylene or absorbable materials are favor of the tissues in-growing and anti-infection. But this kind of patches will cause local tissue inflammation and infection. Fresh materials for patches with outstanding performance and three-dimensional bionics structure must be deeply researched, which will be the most important aspect of hernia patch.