天然胶原半月板组织工程支架修复运动半月板损伤

组织工程学;;运动性半月板损伤;;种子细胞;;可吸收天然胶原;;生物支架材料;;应力刺激;;力学因素 %X 背景：可吸收天然胶原支架材料是成熟和理想的半月板替代物。目的：总结半月板组织工程学研究的现状。方法：以＂组织工程学、运动性半月板损伤、种子细胞、可吸收天然胶原、生物支架材料、应力刺激、力学因素＂为中文关键词,以“Tissueengineering、Movement of the meniscus、Seedcells、Natural collagen can be absorbed、Biological scaffolds、Stress stimulation、Mechanical factor”为英文关键词,采用计算机检索PubMed数据库和维普数据库中1994年1月至2011年12月与运动性半月板损伤及半月板组织工程研究相关的文章。结果与结论：目前的研究重点包括半月板损伤机制、可吸收天然胶原作为半月板组织工程支架的可行性分析、应力刺激、半月板恢复力学因素4个方面。研究表明半月板组织工程修复运动性半月板损伤具有良好的应用前景和广阔的使用空间,但在实际应用中,半月板组织工程支架的构建、细胞外基质复合材料的研究及其与组织的相容性,修复后组织工程半月板的应力刺激和所能承受的力学因素问题仍是半月板组织工程学方面的难点问题。

Natural collagen meniscus tissue engineering scaffolds repair sports-induced meniscus injury

BACKGROUND： Absorbable natural collagen scaffolds are mature and ideal substitutes of the meniscus OBJECTIVE： To review and summarize the research status of studies on meniscus tissue engineering METHODS： A computer-based search of PubMed and VIP databases were performed for articles related to sports-induced meniscus injury and meniscus tissue engineering published from January 1994 to December 2011. The keywords were ＂tissue engineering, movement of the meniscus, seed cells, natural collagen can be absorbed, biological scaffolds, stress stimulation, mechanical factor＂ in English and ＂tissue engineering, sports-induced meniscus injury, seed cells, absorbable natural collagen, biological scaffold, stress stimulation, mechanical factor＂ in Chinese. RESULTS AND CONCLUSION： Currently, we focus on the mechanism of meniscus injury, feasibility of natural collagen used as meniscus tissue engineering scaffold, stress stimulation, mechanical factors associated with meniscus recovery. Studies have demonstrated that meniscus tissue engineering has a good prospect in the repair of sports-induced meniscus injury. However, there are many difficulties in the clinical application of meniscus tissue engineering technology including construction of meniscus tissue engineering scaffolds, extracellular matrix composites and histocompatibility, stress stimulation and mechanical factors following treatment with tissue-engineered meniscus scaffolds.