高分子材料涂覆生物镁合金心血管支架的研究与应用

背景：以高分子材料作为镁合金支架的涂层可改善支架的降解性能及生物相容性。目的：综述镁合金心血管支架表面高分子涂层材料的特点及研究进展。方法：由第一作者检索1995至2010年Elsevier数据库及CNKI数据库有关生物可降解血管支架、生物医用高分子材料和镁合金表面改性等方面的文献。结果与结论：目前镁合金常用的涂覆高分子材料有胶原蛋白、壳聚糖、聚乳酸及其共聚物、有机化合物转化膜、聚氨酯。这些高分子材料均具有好的生物性能,作为镁合金的涂层可以改善镁合金的生物相容性,延缓镁合金的降解时间。但有机物与镁合金之间的结合强度主要依靠物理机械力和化学键合,物理机械力不能够满足要求,必须要对镁合金表面和有机物进行处理,应用合适的表面活性剂使镁合金与有机物之间产生化学键合,从而达到要求。

Research progress of polymer coated biological magnesium alloy coronary stents

BACKGROUND：Polymer coating can improve the degradation and biocompatibility of magnesium alloy stents. OBJECTIVE：To review the properties of polymer coating for magnesium alloy coronary stents. METHODS：The first author searched Elsevier and CNKI databases for relevant articles about biodegradable coronary stents, biomedical polymer materials and surface modification of magnesium alloys published from 1995 to 2010. RESULTS AND CONCLUSION：Polymer materials for coating magnesium alloy include collagen, chitosan, polylactic acid and its copolymers, organic compound conversion coatings, polyurethane. These polymer materials have good biological performance, and can improve the biocompatibility and slow degradation time of the magnesium alloy. However, the bonding strength between the organic and magnesium alloy mainly depends on the physical force and chemical bonding. As the mechanical force cannot meet the requirements, we must deal with the surface of magnesium alloy and organic, and adopt suitable surfactant to produce chemical bonding between the organic and magnesium alloy in order to meet the requirements.