人工韧带与自体腘绳肌腱重建前交叉韧带后的膝关节功能

背景：人工韧带因其不需牺牲自体组织、无潜在传染性疾病、重建韧带后康复时间短等优点,自一面世始终受到到关注。目的：利用Meta分析方法对国内外应用LARS人工韧带与自体腘绳肌腱重建前交叉韧带的对照试验进行Meta分析,从而在较大样本量的前提下评价并比较两种方法重建前交叉韧带在膝关节功能恢复和康复等方面的有效性和安全性。方法：采用电子检索和手工检索进行文献初检,中国期刊全文数据库（CNKI）、中国生物医学数据库（CBM）、维普期刊网（VIP）、Pubmed（medline）,收集国内外关于应用LARS人工韧带与自体腘绳肌腱重建前交叉韧带的对照研究文献,对结果进行Meta分析。其中,试验组以LARS人工韧带为材料重建前交叉韧带,对照组以自体腘绳肌腱为材料重建前交叉韧带。结果与结论：共收集国内外5个临床对照研究,Meta分析结果显示：两组病例术后6个月Lysholm评分,试验组高于对照组,差异有显著性意义。两组病例术后12个月以上Lysholm评分差异无显著性意义。两组病例术后Tegner评分差异无显著性意义。两组病例重建前交叉韧带后kt-2000/1000测量差值差异无显著性意义。分析结果表明,与自体腘绳肌重建前交叉韧带相比,LARS人工韧带短期内的Lysholm评分更高,在更长时间内的Lysholm评分,Tegner评分和kt-2000/1000测量差值上差异不明显。

Knee function after anterior cruciate ligament reconstruction using artificial ligament and autologous hamstring tendon

BACKGROUND：Artificial ligament has been focused since utilization with the advantages of without sacrificing of autologous tissue,no potentially infectious disease,short recovery time after the ligament reconstruction.OBJECTIVE：To analyze the contrast experiment of anterior cruciate ligament reconstruction using ligament advanced renforcement system artificial ligament and autologous hamstring tendon in order to evaluate and compare the efficacy and safety of the two methods on the recovery of knee function.METHODS：Primary screening of the literatures was performed by internet and by hand.Control trial studies regarding the anterior cruciate ligament reconstruction using ligament advanced renforcement system artificial ligament and autologous hamstring tendon were screened out from CBM database,CNKI database,VIP database and PubMed（Medline） database.The results were involved in Meta analysis.Experiment group underwent anterior cruciate ligament reconstruction using ligament advanced renforcement system artificial ligament,while control group underwent anterior cruciate ligament reconstruction using autologous hamstring tendon.RESULTS AND CONCLUSION：Five control trial studies were involved.Meta analysis results have showed that 6 months postoperative Lysholm score in experiment group was higher than that in control group,and the difference was significant.There was no significant difference of over 12 months postoperative Lysholm score between the two groups.There was no significant difference of postoperative Tegner measuring between the two groups.Postoperative kt-2000/1000 score had no statistically significant difference between the two groups.Compared with autologous hamstring tendon in anterior cruciate ligament reconstruction,ligament advanced renforcement system artificial ligament has a higher Lysholm score in short time,and difference of long time Lysholm score,Tegner score and kt-2000/1000 measuring difference is not obvious.