| 尿液氨基末端B型钠尿肽前体与心功能不全的相关性研究 |
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| 引用本文： | 赵法,丛燕,冯磊,张强松,陆一鸣. 尿液氨基末端B型钠尿肽前体与心功能不全的相关性研究[J]. 内科理论与实践, 2011, 6(5): 352-355 |
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| 作者姓名： | 赵法 丛燕 冯磊 张强松 陆一鸣 |
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| 作者单位： | 1. 复旦大学附属华东医院急诊科,上海,200040
2. 上海交通大学医学院附属瑞金医院急诊科,上海,200025 |
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| 摘 要： | 目的：探讨尿液氨基末端B型钠尿肽前体（NT-proBNP）与心功能不全严重程度的相关性,探究其能否作为呼吸困难患者排除心功能不全的筛查指标。方法：以64例确诊为慢性心功能不全的呼吸困难患者建立研究组,以59例其他原因呼吸困难患者为对照组,比较尿液NT-proBNP与血浆NT-proBNP等心功能评价指标相关性及2组间尿液NT-proBNP浓度差异。结果：尿NT-proBNP与血浆NT-proBNP（P〈0.000 1）、左心室射血分数（LVEF）（P〈0.000 1）、左心室舒张期内径（LVEDD）（P=0.000 3）、左心室收缩期内径（LVESD）（P=0.000 5）、左心房前后径（LA）（P〈0.000 1）等心功能评价指标相关,存在统计学意义。2组间尿NT-proBNP差异存在统计学意义（P〈0.000 1）。结论：尿液NT-proBNP浓度反映了慢性心功能不全严重程度,适合作为社区慢性心功能不全预防性筛选的指标。
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| 关 键 词： | 尿液 氨基末端B型钠尿肽前体 心功能不全 |
A preliminary study on correlation between urinary N-terminal pro-B-type natriuretic peptide and severity of cardiac dysfunction |
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| ZHAO Yun,CONG Yan,FENG Lei,ZHANG Qiang-song,LU Yi-ming. A preliminary study on correlation between urinary N-terminal pro-B-type natriuretic peptide and severity of cardiac dysfunction[J]. Joournal of Internal Medicine Concepts& Practice, 2011, 6(5): 352-355 |
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| Authors: | ZHAO Yun CONG Yan FENG Lei ZHANG Qiang-song LU Yi-ming |
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| Affiliation: | ZHAO Yun1,CONG Yan1,FENG Lei1,ZHANG Qiang-song1,LU Yi-ming2.1.Emergency Department,Huadong Hospital Affiliated to Fudan University,Shanghai 200040,China,2.Emergency Department,Ruijin Hospital,Shanghai Jiaotong University Shool of Medicine,Shanghai 200025 |
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| Abstract: | Objective This study was designed to detect the urinary concentration of N-terminal pro-B-type natriuretic peptide(NT-proBNP) in patients with dyspnea and to determine whether it was related to the severity of cardiac dysfunction and could the urinary NT-proBNP be used as a screening marker for discriminating dyspnea patients caused by cardiac dysfunction from that caused by other causes.Methods Sixty-four patients with dyspnea caused by cardiac dysfunction and 59 patients with dyspnea due to other causes w... |
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| Keywords: | Urine N-terminal pro-B-type natriuretic peptide Cardiac dysfunction |
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