A double-blind, randomized, placebo-controlled study of nifedipine on early renal allograft function |
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Authors: | Wilkie, M.E. Beer, J.C. Evans, S.J.W. Raftery, M.J. Lord, R.H.H. Moore, R. Marsh, F.P. |
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Affiliation: | 1The Royal London Hospital Whitechapel, London 2Department of Epidemiology and Medical Statistics, The London Hospital Medical College Mile End Road, London 3Cardiff Royal Infirmary Newport Road, Cardiff UK |
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Abstract: | A double-blind, randomized, placebocontrolled study was conductedto determine the effect of nifedipine on early renal allograftfunction when added to a triple therapy immunosuppression regimecomprising low-dose cyclosporin (CsA), prednisolone and azathioprine.Fifty adult cadaveric renal allograft recipients were randomizedto placebo (group P n=17), nifedipine 10 mg preoperatively and20 mg b.d. postoperatively for 48 h, followed by matching placebofor 3 months (group NS n=16) or nifedipine 10 mg preoperativelyand 20 mg b.d. postoperatively for 3 months (group NL n=17).Donor and recipient exclusion criteria included recent calciumantagonist treatment. At 3 months after transplantation meanGFR adjusted for graft loss was significantly higher in groupNL than in NS (mean ± SD 61±28 versus 34 ±25 ml/min/1.73 m2; P<0.05), group P being intermediate (45± 34ml/min/1.73 m2). Similarly, effective renal bloodflow (ERBF) at 3 months was higher ingroup NL than in groupsP and NS (mean ± SD 351 ± 175 versus 216±166and 220±162 ml/min/ 1.73 m2; P<0.05). The differenceswere not significant by 6 months post-transplantation. Thisstudy suggests that oral nifedipine commenced preoperativelyand continued for 3 months following transplantation has beneficialeffects on early renal allograft function whenincorporated aspart of an immunotherapy regimen based on cyclosporin. |
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Keywords: | renal transplantation early graft dysfunction nifedipine |
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