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Urinary monocyte chemoattractant protein-1 correlates with disease activity in lupus nephritis |
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| Authors: | Stephen D. Marks Vanita Shah Clarissa Pilkington Kjell Tullus |
| Affiliation: | 1. Nephro-Urology Unit, University College London Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK 2. Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK 3. Department of Paediatric Rheumatology, University College London Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK 4. Department of Paediatric Rheumatology, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK |
| Abstract: | Monocyte chemoattractant protein-1 (MCP-1) has a pathogenic role in murine lupus nephritis (LN). We recruited 25 pediatric and adolescent systemic lupus erythematosus (SLE) patients from our lupus clinic [13 (52%) patients with LN and 12 (48%) lupus non-nephritis patients] and evaluated their urinary and plasma MCP-1 levels compared to adult and childhood controls. The median age and SLE disease duration of patients were 14.4 and 5.5 years, respectively. LN patients had a higher median renal (p?=?0.01) British Isles Lupus Assessment Group (BILAG) index, with a tendency for higher total BILAG scores (p?=?0.2). There were significantly increased urinary MCP-1 levels in the LN patients compared to healthy controls (p?pr?=?0.82, p?=?0.04). There were no differences in plasma MCP-1 levels between SLE patient groups and pediatric controls, although the levels in the childhood controls were elevated compared to those of the adult controls (p? |
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