| 中枢神经系统感染患儿脑脊液单胺类物质改变及其机制探讨 |
| |
| 引用本文： | 易咏红,虞佩兰,廖卫平,陆雪芬,郑平,汪润荪.中枢神经系统感染患儿脑脊液单胺类物质改变及其机制探讨[J].中南大学学报(医学版),1994(2). |
| |
| 作者姓名： | 易咏红 虞佩兰 廖卫平 陆雪芬 郑平 汪润荪 |
| |
| 作者单位： | 湖南医科大学附属湘雅医院儿科，湖南医科大学附属湘雅医院神经内科，湖南省儿童医院传染科 |
| |
| 摘 要： | 应用ＨＰＬＣ法测定了结脑、化脑、病脑和对照组患儿脑脊液中单胺类物质。结果发现化脑患者５－ＨＩＡＡ，ＨＶＡ显著高于其它患者；结脑患儿脑脊液中５－ＨＩＡ，ＨＶＡ，ＭＨＰＧ和病脑组患儿Ｔｒｐ，ＨＶＡ浓度与其神经系统功能障碍程度呈正相关。提示脑脊液中单胺物质测定有助于化脑诊断及神经系统损害程度的评估。
|
| 关 键 词： | 脑膜炎 脑炎 儿童 脑脊髓液 生物胺类 |
CHANGES OF MONOAMINES IN CSF OF CHILDREN WITH INFECTIONS OF THE CNS AND ITS
POSSIBLE MECHANISM |
| |
| Yi Yonghong,Yu Peilan.CHANGES OF MONOAMINES IN CSF OF CHILDREN WITH INFECTIONS OF THE CNS AND ITS
POSSIBLE MECHANISM[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),1994(2). |
| |
| Authors: | Yi Yonghong Yu Peilan |
| |
| Institution: | Yi Yonghong,Yu Peilan Department of Pediatrics,Xiangya
Hospital,Hunan Medical University Liao Weiping,Lu Xuefen Department of Neurology,Xingya
Hospital,Hunan Medical University Zheng Ping,Wang Runsun Department of Infectious
Disease,Hunan Childre |
| |
| Abstract: | SF was taken from 45 children with tuberculous
meningitis(14),purulent meningitis(6),viral encephlitis or meningitis(15)and non- neurologic
controls(10).Tryptophan,5-HTP,5-HT,5-HIAA,HVA nd MHPG in CSF were mere measured by a
methos of HPLC .Theresults showeded that the levels of 5-HIAA,HVA in children of purulent
meningitis were sig-nificantly increased as compared with the other 3 groups. Measurement of
5-HIAA andHVA may be used in the differential diagnosis for purulent meningitis. The increased
5-HI-AA was referred to be due to an increased turnover of 5-HT. The concentrations of 5-HI-AA
, HVA, MHPG in patients with tuberculous meningitis,and of tryptophan,HVA in pa-tients with
viral encephanlitis(or meningitis)were positively correlated with the degree ofdisturbed
neurologic function, It indicates that the increased levels of monoamine metabolites may be
used as an index to evaluate the degree of damage of the CNS. |
| |
| Keywords: | meningitis encephalitis child cerebrospinal fluid biological amines |
| 本文献已被 CNKI 等数据库收录！ |
|
