| rhKD/APP对D-氨基半乳糖所致大鼠肝损伤的保护作用 |
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| 引用本文： | 王继萍,冷吉燕,冬冬,颜炜群. rhKD/APP对D-氨基半乳糖所致大鼠肝损伤的保护作用[J]. 临床肝胆病杂志, 2007, 23(1): 24-25 |
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| 作者姓名： | 王继萍 冷吉燕 冬冬 颜炜群 |
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| 作者单位： | 吉林大学第一医院放射科,吉林,长春,130021;吉林大学第一医院干部病房,吉林,长春,130021;吉林大学再生医学研究所,吉林,长春,130021 |
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| 摘 要： | 用D-氨基半乳糖致大鼠肝损伤，以研究rhKD／APP对大鼠肝损伤的保护作用。建立D-氨基半乳糖大鼠肝损伤模型，设空白对照组、模型组、rhKD／APP小剂量组、中剂量组、大剂量组、对照药物抑肽酶组。观察大鼠血清丙氨酸转氨酶（ALT）、天门冬氨酸转氨酶（AST）、总蛋白（TP）、碱性磷酸酶（ALP）、白蛋白（ALB）及肝组织丙二醛（MDA）的含量变化。rhKD／APP可显著降低大鼠血清ALT、AST、ALP的活性及肝组织MDA含量，抑制ALB、TP的降低。rhKD／APP对D-氨基半乳糖所致大鼠肝损伤具有保护作用。
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| 关 键 词： | rhKD/APP D-氨基半乳糖 肝损伤 |
| 文章编号： | 1001-5256（2007）01-0024-02 |
| 收稿时间： | 2006-09-01 |
| 修稿时间： | 2006-09-10 |
The protective effect of rhKD/APP on liver injured by D - galactosamine in rats |
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| WANG Ji - ping, LENG Ji - yan, DONG Dong ,et al.. The protective effect of rhKD/APP on liver injured by D - galactosamine in rats[J]. Chinese Journal of Clinical Hepatology, 2007, 23(1): 24-25 |
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| Authors: | WANG Ji - ping LENG Ji - yan DONG Dong et al. |
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| Affiliation: | Department of Radiology, First Hospital, Jilin University, Changchun 130021, China |
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| Abstract: | To investigate the protective effect of rhKD/APP on liver injured by D - galactosamine in rats. The rat liver injury model was induced by D - galaetosamine, rhKD/APP was given by different dose, compared with controls and aprotinin. The levels of ALT, AST, TP, ALB, ALP in serum and MDA in hepatic tissue were mesured, rhKD/APP can significantly decresease the activities of ALT, AST, ALP, and the content of MDA, and inhibit the decrease of ALB and TP. rhKD/ APP has a protective effect on liver injured by D - galaetosamine in rats. |
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| Keywords: | rhKD/APP D - galaetosamine liver injury |
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