Cryptosporidium parvum infection requires host cell actin polymerization |
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| Authors: | Elliott D A Coleman D J Lane M A May R C Machesky L M Clark D P |
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| Institution: | Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. |
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| Abstract: | The intracellular protozoan parasite Cryptosporidium parvum accumulates host cell actin at the interface between the parasite and the host cell cytoplasm. Here we show that the actin polymerizing proteins Arp2/3, vasodilator-stimulated phosphoprotein (VASP), and neural Wiskott Aldrich syndrome protein (N-WASP) are present at this interface and that host cell actin polymerization is necessary for parasite infection. |
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