Use of glutathione inhibitors and glutathione transferases to overcome tumor resistance to cytostaticsin vivo |
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| Authors: | F. V. Donenko S. M. Sitdikova A. O. Kabieva B. E. Polotskii Z. O. Machaladze M. I. Davydov L. V. Moroz |
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| Affiliation: | (1) Department for the Study of New Antitumor Drugs and Department of Thoracic Oncology, Cancer Research Center, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | Preincubation of cells of BDF1 hybrid mice with P388 leukemia with doxorubicin and buthionine sulfoximine leads to the manifestation of a therapeutic effect of the antibiotic. Injection of buthionine sulfoximine and ethacrinic acid to mice with leukemia does not alter the therapeutic effect of the antibiotic. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N o 2, pp. 212–214, February, 1995 Presented by N. N. Trapeznikov, Member of the Russian Academy of Medical Sciences |
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| Keywords: | glutathione glutathione transferases buthionine sulfoximine ethacrinic acid resistance |
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