| 氟中毒患者姊妹染色单体互换频率和微核率观察 |
| |
| 引用本文： | 梁玉华 吴守伟. 氟中毒患者姊妹染色单体互换频率和微核率观察[J]. 蚌埠医学院学报, 1995, 20(6): 367-369 |
| |
| 作者姓名： | 梁玉华 吴守伟 |
| |
| 作者单位： | 北京首都医学院生物学教研室 |
| |
| 摘 要： | 本文对２４例氟中毒患者的淋巴细胞的培养姊妹染色单体互换（ＳＣＥ）频率和微核率进行观察，结果表明氟中毒患者的ＳＣＥ频率明是业高于正常对照组（ｔ检验，Ｐ〈０．０１），说明氟中毒可引起ＤＮＡ损伤致使ＳＣＥ频率增加，氟中毒患者的淋巴细胞微核率与正常对照组比较（Ｘ＾２）检验Ｐ〈０．０１），患者组明显高于对照组，这说明氟中毒也可引起染色体断裂染色体畸变。
|
| 关 键 词： | 氟中毒 姊妹 染色单体互换 微核率 染色体畸变 |
SISTER CHROMATID EXCHANGE AND MICRONUCLEUS FREQUENCY IN FLUOROSIS |
| |
| Liang Yuhua,Wu Shouwei,Zhang Ding,Pan Weilin. SISTER CHROMATID EXCHANGE AND MICRONUCLEUS FREQUENCY IN FLUOROSIS[J]. Journal of Bengbu Medical College, 1995, 20(6): 367-369 |
| |
| Authors: | Liang Yuhua Wu Shouwei Zhang Ding Pan Weilin |
| |
| Abstract: | Sister chromatid exchange(SCE) and micronucleus frequencies of lymphocyte wereexamined in 24 cases of fluorosis.The results show that SCE and micronucleus frequencies of thesick group are obviously higher than health group. t-test show P<0.001 in SCE,and x2-test showP<0.01 in micronucleus. The results suggest that fluorosis may lead to increase in SCE,chromo-some breakage and aberration. |
| |
| Keywords: | fluorosis sister chromatid exchange(SCE) lymphocyte micronucleus chromoso- mal aberration |
| 本文献已被 CNKI 维普 等数据库收录！ |
