| 印迹基因p57kip2蛋白在水泡状胎块诊断和分型中作用 |
| |
| 引用本文： | 古聪敏,杜家辉,陈永鸿,林汉良. 印迹基因p57kip2蛋白在水泡状胎块诊断和分型中作用[J]. 临床与实验病理学杂志, 2008, 24(3) |
| |
| 作者姓名： | 古聪敏 杜家辉 陈永鸿 林汉良 |
| |
| 作者单位： | 广州市妇婴医院病理科,510180;香港中文大学威尔斯亲王医院病理解剖与细胞学系;中山大学第一附属医院病理科,广州,510080 |
| |
| 摘 要： | 目的 探讨p57kip2蛋白表达在水泡状胎块诊断和分型中的作用和意义.方法 应用免疫组化SP法检测p57kip2蛋白30例在完全性水泡状胎块(complete hydatidiform moles,CHMs)、25例部分性水泡状胎块(partial hydatidiform mole,PHMs)和20例水泡状流产(hydropic abortions,HAs)三组病变中的表达情况,正常成熟胎盘(normal mature placentas,NMPs)为正常对照.结果 p57kip2蛋白在10例NMPs、20例HAs组织中的细胞滋养层细胞、绒毛间质细胞和绒毛外滋养细胞团核表达阳性,合体滋养层细胞不表达;CHMs的绒毛间质细胞和细胞滋养层细胞p57kip2蛋白不表达,阳性表达仅见于绒毛外散在滋养细胞团中;25例CHMs的绒毛间质细胞和细胞滋养层细胞p57kip2均表达阳性.结论 p57kip2蛋白在CHMs和PHMs的表达和分布有明显差异,可作为胎块分型诊断的客观辅助指标,值得在国内妇产科病理诊断常规工作中推广应用.
|
| 关 键 词： | 水泡状胎块 完全性 部分性 基因印迹 p57kip |
Expression of imprinted gene p57~(kip2) in hydatidiform moles |
| |
| GU Cong-min,DU Jia-hui,CHEN Yong-hong,LIN Han-liang. Expression of imprinted gene p57~(kip2) in hydatidiform moles[J]. Chinese Journal of Clinical and Experimental Pathology, 2008, 24(3) |
| |
| Authors: | GU Cong-min DU Jia-hui CHEN Yong-hong LIN Han-liang |
| |
| Affiliation: | 1Department of Pathology;Guangzhou Maternal and Neonatal Hospital;Guangzhou 510180;China;2Department of Anatomical and Cellular Pathology;Prince Wales Hospital;Chinese University of Hong Kong;Shatian;Hong Kong;3Department of Pathology;the First Affiliated Hospital;Sun Yat-sen University;Guangzhou 510080;China |
| |
| Abstract: | Purpose To study the expression of imprinted gene p57kip2 in hydatidiform moles and its effect on differential diagnosis of complete hydatidiform moles(CHMs) from partial hydatidiform moles(PHMs) and hydropic abortions(HAs).Methods In this study,30 cases of CHMs,25 PHMs and 20 HAs were evaluated by immunohistochemistry of formalin-fixed tissues using a monoclonal antibody against p57kip2 protein,a putative paternally imprinted inhibitor gene,while 10 normal mature placentas(NMPs) were as the control.Results... |
| |
| Keywords: | p57kip |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
