染色体介导淋球菌耐药机制的进展

染色体介导的与青霉素及与四环素耐药相关的主要位点包括penA、ponA、penB、penC、mtr及tet。青霉素结合蛋白中出现镶嵌状结构是头孢菌素低敏的原因之一。喹诺酮耐药决定区gyrA和parC不同的位点突变导致喹诺酮耐药。淋球菌对大观霉素高度耐药是由于spe位点单步突变所致。多重耐药与多种位点突变相关。

Molecular Mechanism of Chromosomally Mediated Resistance in Neisseria gonorrheae

The chromosomally mediated penicillin and tetracycline resistance associated genes include penA, ponA, penB, penC, mtr and tet in Neisseria gonorrhoeae. The mosaic-like structure of penicillin-binding protein 2 gene (penA) is associated with reduced susceptibility to cephalosporin. Double gyrA mutations plus a parC mutation play an important role in the development of high-level fluoroquinolone resistance in N. gonorrhoeae. A single-step mutation in spe gene leads to the high-level spectinomycin resistance. The mutations at multiple loci are associated with multidrug-resistant phenotype.