紫背天葵提取物对糖尿病肾病大鼠的作用

目的研究紫背天葵提取物对糖尿病肾病大鼠的作用。方法 SD大鼠一次性腹腔注射链脲佐菌素(STZ),建立糖尿病肾病大鼠模型。紫背天葵提取物(5 g/kg)灌胃4周后,收集大鼠24 h尿液,检测尿液中尿蛋白(UP)、N-乙酰β-D-氨基葡萄糖苷酶(NAG)和β2-微球蛋白(β2-MG)的含量;测定肾脏指数;测定血清中尿素氮(BUN)、肌酐(Cr)和β2-MG的含量。结果紫背天葵提取物能明显降低糖尿病肾病大鼠24 h排尿量、尿蛋白、β2-MG和NAG(P<0.01或0.05);使肾脏指数下降(P<0.05);同时能够降低血清中BUN、Cr和β2-MG含量(P<0.01或0.05)。结论紫背天葵提取物可以改善肾脏滤过功能,明显改善糖尿病肾病大鼠临床症状。

Effects of extract of Begonia fimbristipula on the development of diabetic nephrophathy rats

Purpose To explore the effect of the extract of Begonia fimbristipula on the development of diabetic nephrophathy rats.Methods Diabetic nephrophathy rat models were established by intraperitoneally injecting streptozotocin at the dose of 60 mg/kg.After the diabetic nephrophathy rats were administered with the extract of Begonia fimbristipula by irrigating stomach at the dose of 5 g/kg for 4 consecutive weeks,the urine protein(UP),β-N-acetyl glucosaminidase(NAG) and β2-microglobulin(β2-MG) in urine,and the contents of blood urea nitrogen(BUN),creatinine(Cr) and β2-MG in serum were determined.Results The extract of Begonia fimbristipula could significantly reduce fasting kidney index,24 hours urine collection,UP,NAG,and β2-MG(P<0.01) in urine,and serum BUN,Cr and β2-MG levels(P<0.05) of diabetic nephrophathy rats.Conclusion The extract of Begonia fimbristipula can improve kidney filtration function,and has obviously improved the diabetic nephrophathy rats clinical symptoms.