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An enhanced voxel-based morphometry method to investigate structural changes: application to Alzheimer’s disease |
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| Authors: | Xingfeng Li Arnaud Messé Guillaume Marrelec Mélanie Pélégrini-Issac Habib Benali |
| Institution: | 1. Laboratoire d’Imagerie Fonctionnelle, and LINeM, GHU Pitié-Salpêtrière, Inserm, UPMC Univ Paris 06, UMR_S 678, 91 bd de l’H?pital, 75634, Paris, Cedex 13, France 2. LINeM, International Laboratory of Neuroimaging and Modeling, IUGM, Université de Montréal, 4565 chemin Queen-Mary, Montréal, H3W 1W5, Canada 3. CRM, Université de Montréal, CP 6128, Succursale Centre-ville, Montréal, H3C 3J7, Canada 4. UMR_S 678 Inserm/UPMC, Laboratoire d’Imagerie Fonctionnelle, Faculté de Médecine, CHU Pitié-Salpétrière, 91 Bd de l’H?pital, 75634, Paris Cedex 13, France |
| Abstract: | IntroductionWhen characterizing regional cerebral gray matter differences in structural magnetic resonance images (sMRI) by voxel-based morphometry (VBM), one faces a known drawback of VBM, namely that histogram unequalization in the intensity images introduces false-positive results. |
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