肺炎支原体肺炎患儿免疫功能动态变化及临床意义

目的:探讨肺炎支原体肺炎(MPP)急性期、恢复期患儿外周血中血清免疫球蛋白(IG)、T淋巴细胞亚群、C反应蛋白(CRP)和精制结核菌素(PPD)皮肤试验的动态变化及其临床意义。方法:检测35例MPP急性期及其中24例恢复期血清IgA、IgG、IgM和CRP,外周血CD3、CD4、CD8及做PPD试验,并与正常儿童30例进行比较。结果:MPP组急性期及恢复期较正常儿童的血清IgG及IgA水平降低(急性期P<0.01,恢复期P<0.05),CD3及CD4水平降低(均P<0.01),PPD反应无力(P<0.01),CRP急性期较恢复期及对照组增高(P<0.01)。结论:体液免疫和细胞免疫参与了MPP感染的发病过程,且存在免疫功能降低及紊乱。

Developmental changes and clinical significance of immunological fimction in the cases with mycoplasma pneumoniae pneumonia

Objective:To study the developmental changes and clinical significance of serum immune globulin(IG),T-lymphocyte subsets,Creactive protein(CRP) in peripheral blood and purified aplisol(PPD) skin test in the cases with mycoplasma pneumoniae pneumonia(MPP) in acute and recovery phases.Methods:Detected serum IgA,IgG,IgM,CRP,peripheral blood CD_3,CD_4,CD_8 in 35 cases with acute-phased MPP and the 24 recovery-phased of them;compared them with those of 30 unimpaired children.Results:The serum IgG and IgA levels(the acute-phased P<0.01,the recovery-phased P<0.05),CD_3 and CD_4(mean P<0.01) in the acute-phased and the recovery-phased MPP were lower than those in the unimpaired,with responsive asthenia PPD(P<0.01);the acute-phased CRP increased more than those in the recovery-phased and the controlled(P<0.01).Conclusion:Humoral immunity and cellular immunity involve in the episode of MPP infection,with the presence of decreasing derangement of immunological function.