The effect of an H2-receptor antagonist on small-bowel colonization and bacterial translocation in newborn rats |
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Authors: | Ü N Ba?aran S Celayir N Eray R Öztürk O F ?enyüz |
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Institution: | (1) Department of Pediatric Surgery, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey, TR;(2) Department of Microbiology, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey, TR |
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Abstract: | Bacterial translocation (BT) is defined as the passage of enteric bacteria from the gastrointestinal tract to extraintestinal
tissues. Bacterial overgrowth is one of the main promoting factors of BT, which is thought to play an important role in the
pathogenesis of sepsis and necrotizing enterocolitis. It is believed that small-bowel colonization is established by bacterial
spread through the rectum. Gastric acid is also involved in this process. An experimental study was designed for investigating
the effect of gastric acid inhibition with the use of an H2-receptor antagonist on intestinal colonization and BT in newborn rats. Animals were divided into two groups: the ranitidine
group (n = 20) received ranitidine 10 mg/kg per day intramuscularly for 5 days; the control group (n = 30) received saline solution. Mesenteric lymph node, spleen, liver, stomach, small bowel/cecum, and large bowel specimens
were obtained from each rat 5 days later and gram-negative and -positive aerobic bacteria identified by the use of chocolate
and Endo agar. It is concluded that: (1) there was a strong correlation between gastric and small-bowel bacterial colonization
in the ranitidine group; (2) no correlation between large-and small-bowel colonization could be demonstrated; and (3) BT occurred
only in the ranitidine group.
Accepted: 12 June 1997 |
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Keywords: | Intestinal colonization Bacterial translocation H2-receptor antagonist Ranitidine |
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