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| 绿舒筋生物总碱的体外抗乳腺癌细胞株效应 | |
| 引用本文： | 吴建国,曾凡波,杨敬.绿舒筋生物总碱的体外抗乳腺癌细胞株效应[J].华中科技大学学报(医学版),2003,32(6):665-666. |
| 作者姓名： | 吴建国 曾凡波 杨敬 |
| 作者单位： | 1. 华中科技大学同济医学院职工医院,武汉,430030 2. 华中科技大学同济医学院药学院,武汉,430030 3. 华中科技大学同济医学院基础医学院免疫学系,武汉,430030 |
| 摘 要： | 目的 研究绿舒筋对体外培养乳腺癌细胞株的抑制效应。方法 采用乳酸脱氢酶释放法测定绿舒筋、5-氟尿嘧啶(5-Fu)、环磷酰胺对体外培养乳腺癌细胞株的毒性作用。结果 绿舒筋具有抑制肿瘤细胞生长作用，并随药物浓度增加其效应增强，其效应类似于5-Fu和环磷酰胺。结论 绿舒筋具有较好的抗肿瘤细胞生长作用，可望成为临床抗癌药物。 |
| 关 键 词： | 绿舒筋生物总碱 乳腺癌 细胞株 体外培养 抑制效应 |
Anti-tumor Effect of Euongmus Mupinensis Alkaloid against Glandula Mammae Cancer in vitro |
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| Wu Jianguo ,Zeng Fanbo ,Yang Jing Staff Hospital, School of Pharmacy.Anti-tumor Effect of Euongmus Mupinensis Alkaloid against Glandula Mammae Cancer in vitro[J].Journal of Huazhong University of Science and Technology(Health Sciences),2003,32(6):665-666. | |
| Authors: | Wu Jianguo Zeng Fanbo Yang Jing Staff Hospital School of Pharmacy |
| Institution: | Wu Jianguo 1,Zeng Fanbo 2,Yang Jing 3 1 Staff Hospital,2 School of Pharmacy,3 Institute of Immunology,Tongji Medical College,Huazhong University of Sc ience and Technology,Wuhan 430030 |
| Abstract: | Objective To study the anti-tumor effect o f Euongmus mupinensis alkaloid against the in vitro cultured glandula mammae c ancer cell line. Methods By using the method of lactate dehydrogenase releasing, the toxic actions of Euongmus mupinensis alkaloid, 5-fluorouracil and cyclopho sphamide on the cultured glandula mammae cancer cell line in vitro were meas ured. Results Euongmus mupinensis alkaloid could inhibit the growth o f the tumor in a concentration-dependent manner. The effects were similar to th ose of 5-fluorouracil and cyclophos phamide. Conclusion Euongm us mupinensis alkaloid can inhibit the growth of the tumor. |
| Keywords: | Euongmus mupinensis alkaloid glandula mammae cancer toxic action |
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