Changes in serum levels of hepatitis B virus markers after interferon treatment |
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Authors: | Hiroshi Ikeda MD Kazuharu Matsuura Takao Tsuji |
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Institution: | 1. Department of Internal Medicine, Kurashiki Central Hospital, 1-1-1 Miwa, 710, Kurashiki, Japan
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Abstract: | The effect of interferon (IFN) treatment on serum levels of pre-S antigens pre-S(1) antigen, pre-S(2) antigen, polymerized
human serum albumin receptor (pAR)] which are coded by the pre-S region of hepatitis B virus DNA (HBV-DNA), and HBV-markers
was analyzed in 23 patients with chronic hepatitis B. One year after IFN treatment, 4 patients (Group C) became HBeAg negative.
Six patients (Group B) transiently became HBeAg-negative, but reverted to HBeAg positive. Thirteen patients (Group A) remained
HBeAg positive. All of the patients remained HBsAg-positive. Initiation of IFN treatment was rapidly followed by reduction
or loss of DNA-P in the serum whether the patients became HBeAg negative or remained positive, and whether serum transaminase
(S-GPT) levels became normal or not after IFN treatment. Group C patients, in whom pre-S antigens decreased rapidly during
IFN treatment and disappeared before S-GPT levels normalized, became HBeAg negative one year after IFN treatment. Anti-pAR
was detected in three out of these 4 patients. In contrast, Group A and Group B patients, in whom pre-S antigens decreased
slowly during IFN treatment and did not disappear in spite of those patients being transiently negative for HBeAg and DNA-P,
remained HBeAg positive with elevated S-GPT levels one year after IFN treatment. Anti-pAR was almost undetectable. These results
suggest that testing for pre-S antigens is more useful for determining the prognosis of patients with chronic hepatitis B
treated with IFN than testing for HBsAg, HBeAg and DNA-P. |
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Keywords: | hepatitis B virus interferon polymerized human serum albumin receptor pre-S(1) antigen pre-S(2) antigen |
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