Immunological memory induced byMycobacterium bovis in inbred mice |
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| Authors: | S. V. Khaidukov I. V. Bocharova M. B. Mezhlumova I. S. Litvinov R. T. Yakhin B. V. Nikonenko |
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| Affiliation: | (1) M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow;(2) Central Institute of Tuberculosis, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | Immunological memory was reproduced and studied by subcutaneous vaccination of mice with attenuated strain ofMycobacterium bovis. Ionomycin-resistant cells of CBA mice were for the first time isolated from immune cells and studied as memory T-cells. Previously they were described for another experimental model. They are characterized by high expression of CD3, CD4, CD8, CD28, and α/β-T-cell receptor. The capacity of splenocytes and ionomycin-resistant cells to adoptive transfer of antituberculosis resistance to intact recipients is studied. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 11, pp. 553–555, November, 1997 |
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| Keywords: | experimental tuberculosis Mycobacterium bovis immunological memory ionomycin-resistant T-cells |
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