种植窗口期子宫内膜中MMP-9、TIMP-1及ICAM-1的表达与体外受精-胚胎移植妊娠结局的关系

目的:探讨种植窗口期子宫内膜中MMP-9、TIMP-1和ICAM-1的表达及其与体外受精-胚胎移植妊娠结局的关系。方法:收集40例拟行IVF/ICSI-ET妇女前1周期黄体中期的子宫内膜组织,分别检测妊娠组与非妊娠组中MMP-9、TIMP-1及ICAM-1的表达。结果:与妊娠组相比,非妊娠组中MMP-9、TIMP-1及ICAM-1的表达显著降低,差异有显著性(P<0.05)。结论:种植窗口期子宫内膜中MMP-9、TIMP-1及ICAM-1表达降低,影响胚胎的着床,降低妊娠率,可作为预测IVF/ICSI-ET妊娠结局的指标之一。

The relationship between expression of MMP-9/TIMP-1 and ICAM-1 in the implantation window and the outcome of In Vitro Fertilization and Embryo Transfer

Objective:To investigate the expression of MMP-9,TIMP-1 and ICAM-1 in the planting window of endometrial tissue and the relationship with the pregnancy in IVF.Methods:The midluteal endometrial tissue of the first cycle from 40 women undergoing IVF/ICSI-ET were collected for detecting the expression of MMP-9,TIMP-1 and ICAM-1.The women were divided into two groups,pregnancy group and non-pregnant group Results:The expression of MMP-9,TIMP-1 and ICAM-1 in non-pregnant group was lower than that in pregnant group,and there was significant difference between the two groups(P<0.05).Conclusion:The lower expression of MMP-9,TIMP-1 and ICAM-1 in the endometrial tissue of planting window can affect the implantation of embryo and cause the failure of the pregnancy in IVF.So the expression of MMP-9,TIMP-1 and ICAM-1 in the endometrial tissue of planting window can be used as one of the indicators of pregnancy in the IVF/ICSL-ET.