超声造影诊断肝局灶性结节增生:Meta分析

目的 对超声造影诊断肝局灶性结节增生的研究进行Meta分析,评估其应用价值.方法 检索Pubmed、CBM、CNKI及维普数据库,检索相关文献,采用QUADAS工具进行文献质量评价,分别由两名评价员独立进行文献选择、质量评估及资料提取,应用Meta-disc软件进行统计分析.结果 共纳入7篇文献,质量中等.利用随机效应模型诊断的合并敏感度、特异度分别0.89、0.98,合并阳性似然比为37.89,合并阴性似然比为0.19(P均＜0.1);综合受试者工作特征曲线下面积为0.99,标准误为0.02,各研究间均存在异质性.结论 超声造影对肝局灶性结节增生有较高的诊断价值,通过分析和讨论异质性可提高肝局灶性结节增生的诊断研究水平.

Contrast-enhanced ultrasonographic diagnosis offocal nodular hyperplasia: A Meta-analysis

Objective To assess the value of contrast-enhanced ultrasonographic diagnosis of focal nodular hyperplasia (FNH) with Meta-analysis. Methods Relevant studies in Pubmed, CBM, CNKI and VIP was searched. Study quality was assessed using criteria derived from a quality assessment of diagnostic accuracy studies (QUADAS). Study selection, quality assessment and data extraction were performed by two reviewers independently. Statistical analysis was performed with Meta-disc software. Results Seven studies were included and were found to be of moderate methodological quality. Summary sensitivity and specificity was 0.89 and 0.98, respectively, summary positive likelihood ratio was 37.89, summary negative likelihood ratio was 0.19 (all P<0.1), while weighted area under summary receiver operating characteristic was 0.99, standard error was 0.02. There were heterogeneities in these researches. Conclusion Diagnostic value of FNH with contrast-enhanced ultrasonography is high, and discussing heterogeneity can improve the level of diagnostic research.