艾司西酞普兰与文拉法辛治疗老年抑郁障碍的疗效比较

目的比较艾司西酞普兰与文拉法辛对老年抑郁障碍患者的临床疗效及不良反应。方法将68例符合《中国精神障碍分类与诊断标准》(第3版)抑郁发作诊断标准的老年抑郁障碍患者随机分为2组,分别给予艾司西酞普兰或文拉法辛治疗8周。采用汉密尔顿抑郁量表(HAMD 17)、临床疗效总评量表严重性项目(CGI SI)和治疗时出现的症状量表(TESS)评定疗效和不良反应。结果治疗8周后艾司西酞普兰组有效22例(64.7%),起效7例(20.6%),有效率85.3%,不良反应发生率35.3%;文拉法辛组有效24例(70.6%),起效6例(17.6%),有效率88.2%,不良反应发生率41.2%。2组有效率和不良反应发生率之间差异无统计学意义(P>0.05)。结论艾司西酞普兰与文拉法辛治疗老年抑郁障碍均具有疗效确切,起效较快,不良反应少等优点,适合老年患者使用。

Comparison of efficacy between escitalopram and venlafaxine in treatment of senile depression

A/M To compare efficacy and adverse drug reactions（ADRs） of escitalopram and venlafaxine in the treatment of elderly depression. METHODS Sixty-eight senile depressed patients in line with diagnostic criteria of the CCMD-3 （Chinese Classification of Mental Disorders Version 3 ） were randomly divided into 2 groups and were respec- tively given eseitalopram and venlafaxine for 8 weeks. The efficacy and ADRs in the study were evaluated by HAMD-17 （Hamilton Depression Rating Scale）, CGI-SI （Clinical Global Impression-Serious item） and TESS （Treatment Emergent Symptom Scale）. RESULTS After eight weeks＇ treatment, 22 patients in escitalopram group showed effectiveness and the efficiency rates were 85.3%; 24 patients in venlafaxine group showed effectiveness and the efficiency rates were 88.2%. There was no significant difference between 2 groups,and the incidence of ADRs was 35.3% and 41.2% re- speetively. CONCLUSION These results indicates that escitalopram and venlafaxine in the treatment of elderly depres- sion are both effective, which have faster onset and fewer ADRs and are suitable for elderly patients.