54例药物性肝损伤分析

目的分析药物性肝损伤的临床表现以及所致的可疑药物,探讨药物性肝损伤的特点。方法采用回顾性调查方法,对本院2006-2011年间收住院的54例药物性肝损伤病例进行统计分析。结果 54例药物性肝损害病例中可疑药物以抗结核药居首位,占22.2%;解热镇痛药居第2位,为18.5%;中草药居第3位,占16.7%。临床分型:肝细胞型损伤38例,淤胆型肝损伤6例,混合型肝损伤9例。结论药物性肝损伤的可疑药物主要为抗结核药、解热镇痛药、中草药,特点为隐匿发病,及时发现处理大部分可治愈或好转。

Clinical analysis of 54 cases of drug-induced liver injury

AIM To analyze drug induced liver injury types, clinical manifestations and drag-induced liver injury characteristics,and to provide reference for clinical safe drug use. METIIODS A total of 54 hospital inpafients in 2006 - 2011 with drug-induced liver injury were analyzed statistically. RESULTS In cases of drag-induced liver injury, anti-tuberculosis drugs ranked first, accounting for 22.2%;antipyretic analgesic drags ranked second, accounting for 18.5% ; Chinese herbal medicine ranked third, accounting for 16.7 %. Clinical typing ： hepatocellular injury 38 eases, cholestatie injury 6 eases and mixed type injury 9 eases. CONCLUSION Drag-induced hepatic injury mainly includes anti-tuberculosis drugs, antipyretie analgesic drugs and Chinese herbal medicine. The characteristics of hepatic injury are occult onset, and the partly elinieal symptoms are serious and they can be cured or improved if they are treated timely.