| 水蛭滴眼液防治半乳糖白内障的实验研究 |
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| 引用本文： | 祁明信,黄秀榕,汪朝阳,王勇,林薇,郑良朴,林久茂,叶蕻芝.水蛭滴眼液防治半乳糖白内障的实验研究[J].眼科研究,2001,19(3):220-222. |
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| 作者姓名： | 祁明信 黄秀榕 汪朝阳 王勇 林薇 郑良朴 林久茂 叶蕻芝 |
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| 作者单位： | 福建中医学院 福州,350003 |
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| 基金项目： | 福建省科技厅和福建省教育厅科研基金资助（基金编号：K97045和JK 97124） |
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| 摘 要： | 目的 探讨水蛭滴眼液对半乳糖白内障的防治作用。方法 用SD大鼠复制半乳糖白内障模型，以水蛭为主要成分，配制成水蛭滴眼液，并以白内停滴眼液为阳性对照药，动态观察并比较两组滴眼液对半乳糖白内障的影响。于实验第10天测定两组晶状体的超氧化物歧化酶(SOD)，谷胱甘肽过氧化物酶(GSH-Px)，谷胱甘肽(GSH)和可溶性蛋白(SP)的含量。结果 水蛭组较对照组晶状体混浊速度慢，程度也轻。水蛭组SOD，GSH-Px，GSH的含量均显著高于对照组。结论水蛭滴眼液具有较好的延缓和减轻半乳糖白内障的作用，且优于白内停滴眼液。
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| 关 键 词： | 半乳糖白内障大鼠 水蛭 预防 抗氧化 |
| 修稿时间： | 2000年5月10日 |
Experimental study of
protection and treatment for galactose cataract by leech eye drop |
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| Qi Mingxin, Huang Xiurong, Wang Zhaoyang,et al..Experimental study of
protection and treatment for galactose cataract by leech eye drop[J].Chinese Ophthalmic Research,2001,19(3):220-222. |
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| Authors: | Qi Mingxin Huang Xiurong Wang Zhaoyang |
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| Institution: | Qi Mingxin; Huang Xiurong; Wang Zhaoyang; et al. Traditional Chinese Medicine College of Fujian Fuzhou 350003 |
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| Abstract: | Objective To investigate the protection and treatment effects of leech eye drop on galactose cataract. Meth- cds Animal model of galactose cataract were induced in SD rats. Leech eye drop was mainly composed of leech. Galactose cataract was treated by leech eye drop as experimental group and by pirenoxine sodium(PS) eye drop as control. Lens opacities were observed by FS-3V slit-lamp microscope in two groups. Superoxide dismutase(SOD ), glutathione peroxidase (GSH-Px), glutathione(GSH) and soluble protein (SP) in the lenses were measured at 10 day. Results SOD, GSH-Px, GSH were significantly higher in leech treated group than those in control group (P < 0. 05, P < 0. 01, P < 0. 05, respectively). Conclusion leech eye drops can postpone and alleviate galactose cataract in rats, the effects of leech eye drops are better than those of pirenoxine sodium eye drops. |
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| Keywords: | galactose cataract rat leech prevention anti-oxidation |
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