Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging |
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| Authors: | Xianjin Cui,Salome Belo,Dirk Krü ger,Yong Yan,Rafael T.M. de Rosales,Maite Jauregui-Osoro,Haitao Ye,Shi Su,Domokos Mathe,Noé mi Ková cs,Ildikó Horvá th,Mariann Semjeni,Kavitha Sunassee,Krisztian Szigeti,Mark A. Green,Philip J. Blower |
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| Affiliation: | 1. King''s College London, Division of Imaging Sciences and Biomedical Engineering, 4th Floor Lambeth Wing, St Thomas'' Hospital, London SE1 7EH, UK;2. School of Chemistry, Nottingham University, Nottingham NG7 2RD, UK;3. School of Engineering and Applied Science, Aston University, Birmingham B4 7ET, UK;4. CROmed Ltd., Baross u. 91-95, Budapest H-1047, Hungary;5. King''s College London, Department of Physics, Strand Campus, London WC2R 2LS, UK;6. Department of Biophysics and Radiation Biology, Nanobiotechnology & In Vivo Imaging Center, Semmelweis University, IX. T?zoltó u. 37-47, Budapest H-1094, Hungary;g King''s College London, Division of Chemistry, Britannia House, 7 Trinity St, London SE1 1DB, UK |
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| Abstract: | Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)3 layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [18F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for 18F-fluoride and 100% for 64Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5 min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)3 layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)3 coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of 18F from NPs, but no sign of efflux of 64Cu. |
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| Keywords: | Magnetic nanoparticles PET MR Aluminium hydroxide Dual-modal 18F |
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