Targeting the thyroid gland with thyroid-stimulating hormone (TSH)-nanoliposomes |
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| Authors: | Donatella Paolino Donato Cosco Marco Gaspari Marilena Celano Joy Wolfram Pasquale Voce Efisio Puxeddu Sebastiano Filetti Christian Celia Mauro Ferrari Diego Russo Massimo Fresta |
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| Affiliation: | 1. Department of Health Sciences, University of Catanzaro “Magna Græcia”, Campus Universitario “S. Venuta”, Viale S. Venuta, Germaneto, I-88100 Catanzaro, Italy;2. Department of Experimental and Clinical Medicine, University of Catanzaro“Magna Græcia”, Campus Universitario “S. Venuta”, Viale S. Venuta, Germaneto, I-88100 Catanzaro, Italy;3. Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA;4. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience & Technology of China, Beijing 100190, China;5. Department of Internal Medicine, University of Perugia, 06123 Perugia, Italy;6. Department of Internal Medicine and Medical Specialties, University of Rome “Sapienza”, V.le del Policlinico, 155, 00161 Rome, Italy;g Department of Pharmacy, University of Chieti – Pescara “G. d Annunzio”, Via dei Vestini 31, Chieti 66013, Italy;h Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA;i IRC FSH-Interregional Research Center for Food Safety & Health, University of Catanzaro “Magna Græcia”, Campus Universitario “S. Venuta”, Viale S. Venuta, Germaneto, I-88100 Catanzaro, Italy |
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| Abstract: | Various tissue-specific antibodies have been attached to nanoparticles to obtain targeted delivery. In particular, nanodelivery systems with selectivity for breast, prostate and cancer tissue have been developed. Here, we have developed a nanodelivery system that targets the thyroid gland. Nanoliposomes have been conjugated to the thyroid-stimulating hormone (TSH), which binds to the TSH receptor (TSHr) on the surface of thyrocytes. The results indicate that the intracellular uptake of TSH-nanoliposomes is increased in cells expressing the TSHr. The accumulation of targeted nanoliposomes in the thyroid gland following intravenous injection was 3.5-fold higher in comparison to untargeted nanoliposomes. Furthermore, TSH-nanoliposomes encapsulated with gemcitabine showed improved anticancer efficacy in vitro and in a tumor model of follicular thyroid carcinoma. This drug delivery system could be used for the treatment of a broad spectrum of thyroid diseases to reduce side effects and improve therapeutic efficacy. |
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| Keywords: | Nanoliposomes Nanoparticles Targeting Thyroid cancer Thyroid gland |
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