Predictors of outcome in adults with BCR-ABL negative acute lymphoblastic leukemia treated with a pediatric-based regimen |
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| Authors: | Joseph M. Brandwein Eshetu G. Atenafu Andre C. Schuh Karen W.L. Yee Aaron D. Schimmer Vikas Gupta Mark D. Minden |
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| Affiliation: | 1. Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada;2. Department of Biostatistics, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada |
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| Abstract: | We retrospectively evaluated the outcome of 156 adults age 17–60 with BCR-ABL negative acute lymphoblastic leukemia treated with a pediatric-inspired protocol. The CR rate was 93%; 5-year overall survival (OS) and disease-free survival were 66% and 70%, respectively. Age <34 years and low presenting WBC were independent predictors of favorable OS (p < 0.0001). The 5 year OS of patients age <34 and 34–60 presenting with a low WBC were 85% and 57%, respectively; the 5 year OS for those presenting with a high WBC were 57% and 30%, respectively. Cytogenetics and phenotype were not independent predictors of OS. |
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| Keywords: | Acute lymphoblastic leukemia Leukemia Chemotherapy Prognostic factors |
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