Enhanced dual contrast agent,Co-doped NaYF4:Yb,Tm nanorods,for near infrared-to-near infrared upconversion luminescence and magnetic resonance imaging |
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Authors: | Ao Xia Xiaofeng Zhang Jun Zhang Yunyun Deng Qiang Chen Shishan Wu Xiaohua Huang Jian Shen |
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Affiliation: | 1. Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210046, China;2. School of Chemistry & Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing 210093, China |
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Abstract: | Dual-modality imaging with magnetic resonance (MR) and upconversion luminescence (UCL) is a promising technique for molecular imaging in biomedical research. Multifunctional lanthanide-based nanoparticles have been widely investigated as agents for contrast enhanced MR and fluorescence imaging. However, the use of rare earth fluoride nanoparticles for dual-modality imaging of T2-weighted MR and UCL is rarely reported. We find that NaYF4:Yb3+,Tm3+,Co2+ (MUC) nanorods can be applied as a high-performance dual contrast agent for both T2-weighted MR and UCL dual-modality imaging. After modification with 6-O-carboxymethyl chitosan (OCC), MUC nanorods can be endocytosed by cells without showing signs of cytotoxicity. High-quality UCL images of living cells incubated with MUC-OCC nanorods were acquired on a near-infrared (NIR) confocal microscopy under the excitation at 980 nm. Moreover, MUC-OCC nanorods display high transverse (r2) relaxivities in vitro. The application of low-dose MUC-OCC nanorods for NIR-to-NIR UCL and MR dual-modality in vivo imaging was also carried out successfully. In addition, the toxicity of MUC-OCC nanorods was evaluated by MTT assay, serological tests and histological analysis of visceral organs. |
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Keywords: | Upconversion luminescence Nanorod Magnetic resonance imaging Multi-modality imaging Rare earth nanomaterials Lanthanide nanoparticle |
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