Stathmin 1 is involved in the highly proliferative phenotype of high-risk myelodysplastic syndromes and acute leukemia cells |
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| Authors: | João Agostinho Machado-Neto Paula de Melo Campos Patricia Favaro Mariana Lazarini Irene Lorand-Metze Fernando Ferreira Costa Sara Teresinha Olalla Saad Fabiola Traina |
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| Institution: | 1. Hematology and Hemotherapy Center – University of Campinas/Hemocentro – Unicamp, Instituto Nacional de Ciência e Tecnologia do Sangue, Campinas, São Paulo, Brazil;2. Department of Biological Sciences, Federal University of São Paulo, Diadema, São Paulo, Brazil;3. Department of Internal Medicine, University of São Paulo at Ribeirão Preto Medical School, Ribeirão Preto, São Paulo, Brazil |
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| Abstract: | Stathmin 1 is an important cytoplasmic microtubule-destabilizing protein that plays critical roles in proliferation and accurate chromosome segregation through regulation of microtubule dynamics. High levels of Stathmin 1 expression have been reported in leukemia and solid tumors. However, Stathmin 1 has not been studied in myelodysplastic syndrome cells. We, herein, report that significantly higher Stathmin 1 levels were observed in proliferating hematopoietic cells, in high-risk MDS and acute leukemia cells. In addition, Stathmin 1 silencing in U937 and Namalwa leukemia cells reduced cell proliferation and clonogenicity. Our data suggest that Stathmin 1 expression may be related to the highly proliferative phenotype of hematopoietic cells and add new insights into the participation of Stathmin 1 in hematological malignancies. |
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| Keywords: | Stathmin 1 OP18 Myelodysplastic syndromes Acute myeloid leukemia Acute lymphoid leukemia |
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