Role of minimal residual disease and chimerism after reduced-intensity and myeloablative allo-transplantation in acute myeloid leukemia and high-risk myelodysplastic syndrome |
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| Authors: | Teresa Bernal,Marí a Diez-Campelo,Vicky Godoy,Silvia Rojas,Enrique Colado,Miguel Alcoceba,Marcos Gonzá lez,Belé n Vidriales,Fermí n M. Sá nchez-Guijo,Lucí a Ló pez-Corral,Elisa Luñ o,Consuelo del Cañ izo |
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| Affiliation: | 1. Servicio de Hematología y Hemoterapia, Hospital Universitario Central de Asturias, Oviedo, Spain;2. Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain |
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| Abstract: | We evaluated the impact of detection of minimal residual disease by flow cytometry (FCMRD) and CD3 chimerism in relapse in a cohort of 87 patients with acute myeloid leukemia or myelodysplastic syndrome undergoing stem cell transplantation. Patients with a positive FCMRD at day +100 after transplantation showed higher relapse rates and worse overall survival. In multivariate analysis, a positive FCMRD after transplantation was a significant predictor of relapse. Mixed chimerism showed a trend to statistical signification. We conclude that FCMRD at day 100 after SCT is the best predictor of relapse after SCT in patients with aggressive myeloid malignancies. |
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| Keywords: | Minimal residual disease Chimerism Allogeneic stem cell transplantation Acute myeloid leukemia Myelodysplastic syndrome Relapse |
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