X-ray CT guided fault-free photothermal ablation of metastatic lymph nodes with ultrafine HER-2 targeting W18O49 nanoparticles |
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| Authors: | Da Huo Jian He Hui Li Ai J. Huang Hui Y. Zhao Yin Ding Zheng Y. Zhou Yong Hu |
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| Affiliation: | 1. Institute of Materials Engineering, National Laboratory of Solid State Microstructure, College of Engineering and Applied Sciences, Nanjing University, Jiangsu 210093, PR China;2. Department of Radiology, Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing 210093, PR China;3. Department of Laboratory Medicine, Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing 210093, PR China;4. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Jiangsu 210093, PR China |
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| Abstract: | Designing high accuracy in the diagnosing and fault-freely eliminating lymphatic metastasis of breast malignancy, to avoid the invasiveness and complications caused by traditional assays, is of great therapeutic importance. To this end, theranostic W18O49 nanoparticles targeting to human epidermal growth receptor 2 (HER-2) over-expressed breast malignancy were synthesized via polyol method. By taking advantage of their high X-ray attenuating and photothermotherapy potency, lymph nodes in the mice bearing HER-2 positive metastasis could be clearly distinguished under CT guidance and selectively eliminated by laser ablation. The therapeutic efficacy was further confirmed by the significantly extended survival period. These finding evidenced the potential of these nanoparticles for imaging guided photothermal ablation of HER-2 positive breast malignancy. |
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| Keywords: | Nanoparticles Computed tomography Tungsten oxide Metastasis Photothermal therapy HER-2 |
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