The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation |
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| Authors: | Katrine Brandt Mortensen Thomas Alexander Gerds Ole Weis Bjerrum Anders Lindmark Henrik Sengeløv Christen Lykkegaard Andersen |
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| Institution: | 1. Department of Hematology, Copenhagen University Hospital, Copenhagen, Denmark;2. Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark;3. Department of Hematology, Roskilde Hospital, Roskilde, Denmark |
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| Abstract: | The prognostic significance of eosinophilia after myeloablative allogeneic stem cell transplantation (ASCT) remains to be established. Patients, whom developed chronic graft-versus-host disease (cGVHD) after ASCT, were included (n = 142). Eosinophil count was analyzed at cGVHD onset. We observed no significant association between EO and the grade of cGVHD, thrombocytopenia, nor extensive skin involvement. Importantly, we observed no significant association between cGVHD with concomitant eosinophilia and long-term clinical outcomes, and subgroup analyses revealed a considerable confounding effect of ongoing steroid treatment. In conclusion, we advocate that prognostic conclusions regarding cGVHD with concomitant eosinophilia after ASCT should be interpreted with caution. |
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| Keywords: | Allogeneic stem cell transplantation Chronic graft-versus-host disease Eosinophilia Glucocorticoids Myeloablative Clinical outcome |
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