| 端粒酶活性的原位检测在食管癌早期诊断中的意义 |
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| 引用本文： | 钱晓彬,曹友清,陈淼,成静.端粒酶活性的原位检测在食管癌早期诊断中的意义[J].中华肿瘤防治杂志,2002,9(6):585-586. |
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| 作者姓名： | 钱晓彬 曹友清 陈淼 成静 |
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| 作者单位： | 1. 江苏大学医学院病理教研室,江苏,镇江,212001
2. 江苏大学医学院免疫教研室,江苏,镇江,212001 |
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| 基金项目： | 江苏省科委社会发展项目 (BS2 0 0 0 3 93 ) |
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| 摘 要： | 目的 :研究端粒酶活性的原位检测在食管癌早期诊断中的意义。方法 :应用原位杂交技术检测30例食管癌组织、癌旁组织及其正常黏膜中端粒酶mRNA的表达显示端粒酶的活性。结果 :端粒酶活性在食管癌组织中阳性表达率显著性高于癌旁组织、正常黏膜。结论 :端粒酶的原位检测对食管癌的早期诊断有一定意义。
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| 关 键 词： | 端粒 端粒 末端转移酶代谢 端粒 末端转移酶分析 食管肿瘤早期诊断 原位杂交 |
| 文章编号： | 1009-4571(2002)06-0585-02 |
| 修稿时间： | 2002年4月10日 |
Telomerase Activety Detected in Suit for the Early Diagnosis of Esophageal Cancer |
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| QIAN Xiao bin,CAO You qing,CHEN Miao,et al..Telomerase Activety Detected in Suit for the Early Diagnosis of Esophageal Cancer[J].Chinese Journal of Cancer Prevention and Treatment,2002,9(6):585-586. |
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| Authors: | QIAN Xiao bin CAO You qing CHEN Miao |
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| Institution: | QIAN Xiao bin,CAO You qing,CHEN Miao,et al.Department of Pathology,Medical of Jiangsu University,Zhenjiang 212001,China |
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| Abstract: | Objective To study the significance of telomerase activity in the early diagnosis of esophageal cancer.Methods Telomerase activity was detected by using hybridization in situ of telomerase mRNA in cancer tissues,adjacent cancer tissues,normal tissues from patients with esophageal cancer.Results The expression of telomerase activity in cancer tissues showed higher than those in adjacent cancer tissuesand normal tissues.Conclusions There is significance to detected telomerase activity in situ for the early diagnosis of esophageal cancer. |
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| Keywords: | telomere telomerase/metabolism telomerase/analytical esophageal neoplasms/diagnosis in situ hybrididiaztion |
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