Primary intracranial germ cell tumours: Experience of a single South-East Asian institution |
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| Affiliation: | 1. Department of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Dr, S169610, Singapore;2. Department of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, Singapore;3. Therapeutic Radiology Department, National Cancer Centre Singapore, Singapore;1. Neurosurgery Department, The Walton Centre NHS Foundation Trust, Lower Lane, Fazakerley, Liverpool, L9 7LJ, UK;2. School of Medicine, University of Liverpool, Liverpool, UK;3. Department of Medicine and Medical Mycology, University Hospital of South Manchester, Manchester, UK;4. Microbiology Department, Aintree University Hospital NHS Foundation, Liverpool, UK;5. Otolaryngology Department, The Shrewsbury and Telford Hospital NHS Trust, Shrewsbury, UK;6. Otolaryngology Department, Aintree University Hospital NHS Foundation, Liverpool, UK;7. Neurosurgery Department, Beaumont Hospital, Dublin, Ireland;1. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Dongcheng District, Beijing 100050, China;2. INI Stroke Center & Stroke Network, OSF Healthcare System, University of Illinois College of Medicine, Peoria, IL, USA;1. Division of Nuclear Medicine, European Institute of Oncology, via Ripamonti 435, 20141 Milan, Italy;2. Division of Medical Physics, European Institute of Oncology, via Ripamonti 435, 20141 Milan, Italy;1. Department of Neurology, Hadassah-Hebrew University Medical Center, P.O. Box 12000, Jerusalem 91120, Israel;2. Department of Neurosurgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel;3. Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel;1. Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA, USA;2. Department of Pathology, University of California at San Francisco, San Francisco, CA, USA;3. Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 676 N. St. Clair St, Suite 2210, Chicago, IL 60611-2911, USA;1. Affiliated Liuzhou Hospital of Southern Medical University, Liuzhou, Guangxi, China;2. The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China;3. Foshan Hospital of Traditional Chinese Medicine, Guangdong, China;4. The First People’s Hospital of Nanning, Nanning, China;5. Zhongshan Chenxinghai Hospital, Guangdong, China;6. Institute of Hospital Management, Chinese PLA General Hospital, Beijing, China;7. Continuing Learning College of Guangzhou University, Guangdong, China |
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| Abstract: | Primary intracranial germ cell tumours (ICGCT) are a rare group of brain tumours arising predominantly in the paediatric and pre-adult population, accounting for up to 9.5% of paediatric brain tumours in East Asia. The National Cancer Centre Singapore (NCCS) is a tertiary referral centre for patients from all over South-East Asia. Our study aims to describe the characteristics of ICGCT patients in South-East Asia. Data on all patients with ICGCT who were seen at the Therapeutic Radiology Department of NCCS from 2000 to 2013 were collected retrospectively. Patient demographics, disease characteristics and treatment outcomes were analysed. Characteristics and survival of our patients were similar to other centres. Pure germinomas demonstrated 5 year overall survival (OS) and disease-free survival (DFS) rates of 89.2% (95% confidence interval [CI] 60.2–97.5) and 85.2% (95%CI 60.8–95.0) respectively. Secreting germinomas, non-germinomatous germ cell tumours and mixed germ cell tumours were evaluated together and demonstrated 5 year OS of 70.6% (95%CI 41.0–87.3) and DFS of 61.4% (95%CI 31.9–81.3). Patients ⩽12 years had marginally better 5 year OS than their older counterparts (81.0% [95%CI 49.5–93.9] versus 77.9% [95%CI 47.3–92.0], respectively). Patients who underwent extended field radiotherapy had longer OS and DFS than those who received local field irradiation. Treatment outcomes of our ICGCT patients are comparable with those in other Asian and Western centres. Extended field radiotherapy is a pivotal component of ICGCT treatment. Adding chemotherapy confers no extra survival benefit in treating germinomas. Treatment of mixed germ cell tumours and non-germinomatous germ cell tumours involves a multidisciplinary approach that varies for each histological subtype. |
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| Keywords: | Germ cell tumour Intracranial Mixed germ cell tumours NGGCT |
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