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Behavioral comorbidity in children and adolescents with epilepsy
Affiliation:1. Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar East, Gautam Nagar, New Delhi 110029, India;2. Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India;3. Department of Pediatrics, SMS Medical College, Jaipur, Rajasthan, India;1. Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China;2. Department of Neurosurgery, School of Medicine, Southern Medical University (Guangzhou), Jinling Hospital, Nanjing, Jiangsu Province, China;3. Department of Pharmacology, Jinling Hospital, Nanjing 210002, Jiangsu Province, China;1. Melbourne Brain Centre, Royal Melbourne Hospital, Parkville, VIC, Australia;2. Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia;3. Department of Mathematics and Statistics, The University of Melbourne, Melbourne, VIC, Australia;4. Neurointervention Service, Department of Radiology, Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia
Abstract:This cross sectional study assessed the prevalence of behavioral comorbidity and its association with epilepsy-related factors in children and adolescents with epilepsy. One hundred consecutive patients with active epilepsy, aged 6–16 years, were screened for behavioral comorbidity using the Child Behavior Checklist and those who qualified as having behavioral comorbidity were compared with those who did not have it. Behavioral comorbidity was found in 43 of 100 participants. Being treated with antiepileptic drug polytherapy (odds ratio 6.3, 95% confidence interval 1.4–17.3, p = 0.01) independently predicted behavioral comorbidity in the patients studied. The demonstrated high frequency of behavioral comorbidity in children with epilepsy suggests that pediatricians and pediatric neurologists should be sensitive to this fact in order to identify and manage behavioral comorbidity in children with epilepsy.
Keywords:Antiepileptic drugs  Behavioral comorbidity  Child behavior checklist  Epilepsy
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