Biodistribution and radiation dosimetry in humans of [11C]FLB 457, a positron emission tomography ligand for the extrastriatal dopamine D2 receptor |
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| Institution: | 1. Department of Nuclear Medicine, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands;2. Graduate School of Neurosciences, Amsterdam, The Netherlands;3. Department of Nuclear Medicine, Medical Center Alkmaar, Alkmaar, The Netherlands;4. Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands;5. Department of Anatomy and Neurosciences, VU Medical Center, Amsterdam, The Netherlands;1. Institute for Clinical Medicine, Aarhus University, Aarhus, Denmark;2. Protein Chemistry Laboratory, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark;3. Department of Cardiology, Aarhus University Hospital, Skejby, Denmark;4. Department of Nuclear Medicine, Aarhus University Hospital, Aarhus, Denmark;1. Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul 135–710, Korea;2. Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul 135–710, Korea |
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| Abstract: | Purpose11C]FLB 457, a radioligand with very high affinity and selectivity for dopamine D2/3 receptors, is used to measure receptor binding in extrastriatal regions showing low density of the receptors. The purpose of this study was to estimate the whole-body biodistribution of radioactivity and the radiation absorbed doses to organs after intravenous injection of 11C]FLB 457 in healthy human subjects.MethodsWhole-body images were acquired for 2 h after an injection of 11C]FLB 457 in six healthy humans. Radiation absorbed doses were estimated by the MIRD scheme implemented in OLINDA/EXM 1.1 software.ResultsOrgans with the longest residence time were the liver, lungs, and brain. The organs with the highest radiation doses were the kidneys, liver, and pancreas. The effective dose delivered by 11C]FLB 457 is 5.9 μSv/MBq, similar to those of other 11C-labeled tracers.ConclusionsThis effective dose would allow multiple scans in the same individual based on prevailing maximum recommended-dose guidelines in the USA and Europe. |
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