运动对儿童青少年1型糖尿病患者骨骼的影响

1型糖尿病发病高峰期与骨量积累关键期重合。1型糖尿病会引发患者生长激素/胰岛素样生长因子-1轴改变,导致成年后峰值骨量偏低,增加未来发生骨质疏松和脆性骨折的风险。本研究通过查阅国内外文献,对儿童和青少年阶段1型糖尿病患者骨密度、骨代谢、骨结构、骨材料性特征、运动改善该阶段患者骨量的主要机制以及不同运动方式的干预特点进行综述。

Effects of exercise on the bone of children and adolescents with type 1 diabetes

Objective The peak period of type 1 diabetes incidence coincides with the critical period of bone mass accumulation. Type 1 diabetes can cause changes in the growth hormone/insulin-like growth factor-1 axis in patients, resulting in lower peak bone mass in adulthood and an increased risk of future osteoporosis and fragility fractures. In this study, by reviewing domestic and foreign literature, the bone mineral density, bone metabolism, bone structure, bone material characteristics, the main mechanism of exercise to improve bone mass in children and adolescents with type 1 diabetes mellitus, and the intervention characteristics of different exercise methods were reviewed.