Plasma brain natriuretic peptide is elevated in the acute phase of intracerebral hemorrhage |
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| Institution: | 1. Interdepartmental Division of Critical Care and Department of Medicine, University of Toronto, 399 Bathurst Street, 2 McLaughlin 411P, Toronto, ON Canada M5T 2S8;2. Department of Medicine, University of Toronto, Toronto, ON, Canada;3. Department of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada;4. Department of Medical Imaging, Toronto Western Hospital, University Health Network, Toronto, ON, Canada;1. Neurology Service, Cruces University Hospital, Department of Neurosciences, University of the Basque Country, Plaza de Cruces, s/n., Baracaldo, Vizcaya CP 48993, Spain;2. Neurophysiology Service, Cruces University Hospital, Vizcaya, Spain;1. Department of Molecular Neurobiology and Neuropathology, National Institute of Neurology, La Rabta, Tunis, Tunisia;2. National Institute on Aging, Porter Neuroscience Research Center, National Institutes of Health, Building 35, Room 1A1010, Bethesda, MD 20892, USA;3. Laboratory of Biochemistry, Rabta Hospital, Tunis, Tunisia;1. Department of Neurology, Klinikum Großhadern, Ludwig-Maximilians-University, Marchioninistr. 15, Munich 81377, Germany;2. Schoen-Klinik Bad Aibling, Bad Aibling, Germany;1. Child Neurology Division, Department of Pediatrics, Sapienza University of Rome, Viale Regina Elena 324, Rome 00161, Italy;2. Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy;3. Department of Experimental Medicine, Sapienza University of Rome, Italy;4. Department of Educational Processes, Chair of Pediatrics, University of Catania, Italy |
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| Abstract: | Previous reports have shown that plasma brain natriuretic peptide (BNP) levels are increased in patients with subarachnoid hemorrhage and ischemic stroke. We examined BNP in patients with intracerebral hemorrhage (ICH). Between June 2006 and February 2010, we prospectively enrolled consecutive patients with acute ICH within 24 hours of onset. The plasma BNP level was measured twice, on admission and 4 weeks after onset or at discharge. We investigated whether plasma BNP was elevated in the acute phase of ICH and associated factors. The mean ± standard deviation (SD) plasma BNP level of all patients was 71.1 ± 104.1 pg/mL. The log BNP level positively correlated with the cardio–thoracic ratio (r = 0.240, p = 0.0001). Moreover, BNP was significantly associated with intraventricular extension (p = 0.0039) and hydrocephalus (p = 0.0046). The mean ± SD BNP level of patients with cerebellar hemorrhage was the highest (130.2 ± 152.0 pg/mL), followed by brainstem (84.5 ± 170.6 pg/mL), lobar (72.4 ± 148.1 pg/mL), thalamus (64.8 ± 72.1 pg/mL), and putamen (59.9 ± 62.6 pg/mL) hemorrhages. In 185 patients, BNP was measured in the subacute phase of ICH. The BNP level in the acute phase of ICH was significantly higher than that in the subacute phase of ICH (69.3 ± 108.1 versus 21.7 ± 23.5 pg/mL, p < 0.0001). In conclusion, plasma BNP appears to be elevated in the acute phase of ICH, particularly in those with cerebellar lesions. |
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| Keywords: | Brain natriuretic peptide Hydrocephalus Intracerebral hemorrhage Intraventricular extension |
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