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Dural-based Rosai–Dorfman disease: Differential diagnostic considerations
Institution:1. Department of Neurosurgery, University Medical Center Mannheim, Mannheim, Germany;2. Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg and Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany;3. Department of Neurosurgery, Knappschafts-Krankenhaus Bochum-Langendreer, Ruhr-University of Bochum, In der Schornau 23-25, 44892 Bochum, Germany;1. Department of Neurosurgery, Austin Health, The University of Melbourne, 145 Studley Road Heidelberg, VIC 3070, Australia;2. Department of Anatomical Pathology, Austin Health, The University of Melbourne, VIC, Australia;1. Department of Anatomic Pathology, L25, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA;2. Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, OH, USA
Abstract:Extranodal sinus histiocytosis with massive lymphadenopathy (Rosai–Dorfman disease) is a non-neoplastic condition that has rarely been reported to involve the central nervous system. This report documents a 28-year-old man with Rosai–Dorfman disease who presented with a seizure and a dural-based mass that was thought to represent a meningioma. Resection showed a lesion marked by large, S-100 protein immunoreactive histiocytic cells with intermixed benign lymphocytes and plasma cells. Emperipolesis with intracytoplasmic lymphocytes and plasma cells was present. Differential diagnostic considerations will be discussed.
Keywords:Brain tumor  Dural mass  Extranodal sinus histiocytosis with massive lymphadenopathy  Rosai–Dorfman disease
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