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Relapsing polymyositis in chronic graft versus host disease
Affiliation:1. Department of Neurosurgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China;2. Shanghai Key Lab of Medical Image Computing and Computer Assisted Intervention, Shanghai, China;1. Department of Neurosurgery, Division of Spine Surgery, Paris Descartes University and Sainte-Anne University Hospital, Paris, France;2. Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, 901 Walnut Street, 3rd Floor, Philadelphia, PA 19107, USA;3. Department of Neurosurgery, Hotel Dieu de France, Beirut, Lebanon;1. Department of Neurosurgery, Hadassah-Hebrew University Medical Center, POB 12000, Jerusalem 91120, Israel;2. Department of Endovascular Neurosurgery and Interventional Neuroradiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel;3. Department of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel;1. Department of Neurosurgery, University Medical Center Mannheim, Mannheim, Germany;2. Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg and Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany;3. Department of Neurosurgery, Knappschafts-Krankenhaus Bochum-Langendreer, Ruhr-University of Bochum, In der Schornau 23-25, 44892 Bochum, Germany
Abstract:Chronic graft versus host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation, which contributes to the morbidity and mortality of transplant patients. A polymyositis pattern of injury is a rare manifestation of chronic GVHD in skeletal muscle after hematopoietic stem cell transplantation. We report a 54-year-old man with acute myeloid lymphoma who underwent an allogeneic bone marrow transplantation and subsequently developed acute gastrointestinal GVHD 2 months post-transplantation and polymyositis 14 months post-transplantation. Upon tapering of steroids, the patient experienced a relapse of polymyositis. The literature on polymyositis in chronic GVHD is briefly reviewed.
Keywords:Bone marrow transplantation  Graft versus host disease  Polymyositis  Relapsing graft versus host disease
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