壮族居民生命早期经历饥荒与成年后中心型肥胖的相关性研究

目的 探讨壮族居民生命早期饥荒经历与成年后中心型肥胖的关系。方法 将1 279名在1959—1961年经历饥荒的研究对象分为未经历组(1963年之后出生)、胎儿期经历组(1959—1962年出生)、儿童期经历组(1949—1958年出生)、青春期经历组(1941—1948年出生),采用二分类logistic回归模型评估壮族居民生命早期饥荒暴露与成年后中心型肥胖的关系。结果 壮族居民成年后中心型肥胖的发生率为30.88%。与未经历暴露人群相比，胎儿期暴露(OR=3.527,95%CI:1.877～6.627)和儿童期暴露(OR=2.863,95%CI:1.3297～6.167)的壮族居民成年后中心型肥胖的风险较高。结论 壮族居民生命早期经历饥荒是成年后中心型肥胖的危险因素。经历饥荒的广西壮族居民，应关注中心型肥胖发生情况，预防其他相关慢性病。

Relevance of serious famine experience in early life and adult central obesity of the Zhuang residents

Objective To explore the relationship between famine experience in early life and central obesity in adults of Zhuang nationality. Methods A total of 1 279 subjects who experienced famine between 1959 and 1961 were divided into four groups: unexperienced group(born after 1963), fetal experience group(born between 1959 and 1962), childhood experience group(born between 1949 and 1958), and adolescent experience group(born between 1941 and 1948). Binary logistic regression model was used to evaluate the relationship between famine exposure in early life and adult central obesity in Zhuang residents. Results The incidence of the central obesity of Zhuang residents has been 30.88%. Compared to Zhuang residents with adolescence exposure and unexposed people, the ones with fetal exposure(OR=3.527, 95% CI: 1.877-6.627)and children’s exposure(OR=2.863, 95% CI: 1.3297-6.167)had higher risk of obesity when became adults. The bigger the exposure of famine, the greater the risk of central obesity of Zhuang adult residents(P<0.05). Conclusion Experience of famine in early life is a risk factor for central obesity in adults. The famine-stricken Zhuang residents in Guangxi should pay attention to the occurrence of central obesity and prevent other related chronic diseases.