The role of fibroblast growth factor receptor 4 polymorphisms in the susceptibility and clinical features of ischemic stroke |
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| Affiliation: | 1. Department of Neurology, Hongqi Hospital, Mudanjiang Medical University, Aimin District, Mudanjiang 157011, China;2. Department of Neurology, First Hospital, Ji Lin University, Chang Chun 130021, China;1. Interdepartmental Division of Critical Care and Department of Medicine, University of Toronto, 399 Bathurst Street, 2 McLaughlin 411P, Toronto, ON Canada M5T 2S8;2. Department of Medicine, University of Toronto, Toronto, ON, Canada;3. Department of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada;4. Department of Medical Imaging, Toronto Western Hospital, University Health Network, Toronto, ON, Canada;1. Neurocritical Care Division, Institute for Neurosciences, Capital Regional Medical Center, 750 Brunswick Avenue, Trenton, NJ 08638, USA;2. Medical Neuroendocrinology Section, Program for Reproductive and Adult Endocrinology, National Institutes of Health, Bethesda, MD, USA;3. Neurosonology Division, Thomas Jefferson Hospital, Philadelphia, PA, USA;4. Department of Neurology, Thomas Jefferson Medical Center, Philadelphia, PA, USA;1. Department of Neurology, Klinikum Großhadern, Ludwig-Maximilians-University, Marchioninistr. 15, Munich 81377, Germany;2. Schoen-Klinik Bad Aibling, Bad Aibling, Germany;1. Neurology Service, Cruces University Hospital, Department of Neurosciences, University of the Basque Country, Plaza de Cruces, s/n., Baracaldo, Vizcaya CP 48993, Spain;2. Neurophysiology Service, Cruces University Hospital, Vizcaya, Spain |
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| Abstract: | Some polymorphisms in the fibroblast growth factor receptor 4 gene (FGFR-4) have been correlated with coronary artery disease, however, the role of polymorphisms in the FGFR-4 gene in ischemic stroke remain unknown. A total of 270 patients with ischemic stroke and 297 controls were recruited. Stroke subtype was classified and clinical severity of stroke in patients was evaluated. The polymorphisms in the FGFR-4 were genotyped. There were no significant differences of genotype distributions and allele frequencies of rs145302848C/G and rs147603016G/A between stroke patients and controls (all p > 0.05). However, genotype frequencies and allele frequencies at rs351855G/A (Gly388Arg) were significantly different between stroke patients and controls (both p < 0.001). With the rs351855GG genotype as a reference, the presence of rs351855AA homozygote had a significantly increased risk for stroke (adjusted odds ratio 2.663; 95% confidence interval 1.673–4.229, p < 0.001). The polymorphisms at rs145302848C/G and rs147603016G/A did not influence the susceptibility of stroke in this study. All FGFR-4 polymorphisms were not associated with clinical features such as Trial of Org 10172 in Acute Stroke Treatment subtype or stroke severity as indicated by mean National Institutes of Health Stroke Scale scores. Our study suggests a positive association between FGFR-4 gene polymorphism at rs351855G/A and susceptibility to ischemic stroke. |
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| Keywords: | Chinese Fibroblast growth factor receptor 4 Ischemic stroke Polymorphisms Susceptibility |
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