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Audiological evidence of therapeutic effect of steroid treatment in neuromyelitis optica with hearing loss
Affiliation:1. Department of Otolaryngology-Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan;2. Department of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan;3. Laboratory of Rehabilitative Auditory Science, Tohoku University Graduate School of Biomedical Engineering, Sendai, Miyagi, Japan;1. Department of Neurosurgery, Hebei Medical University, Shijiazhuang, China;2. Department of Functional Neurosurgery, Hebei General Hospital, No. 348 Heping West Road, Shijiazhuang 050000, China;3. Department of Pathology, Hebei General Hospital, Shijiazhuang, China;1. Neurology Service, Hospital Universitario Virgen de las Nieves, Avenida Juan Pablo II, S/N, 18013 Granada, Spain;2. Neurology Department, Complexo Hospitalario de Pontevedra, Pontevedra, Spain;3. Neurology Department, Complexo Hospitalario Universitario de A Coruña, As Xubias, A Coruña, Spain;4. Medical Department, TEVA Pharmaceutical Ltd., Alcobendas, Spain;1. Department of Pathology, Division of Neuropathology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 626, Rochester, NY 14623, USA;2. Department of Pathology, Division of Neurosurgery, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA;3. Department of Urology, State University of New York, Upstate Medical University, Syracuse, NY, USA;1. Department of Ophthalmology, University of Oklahoma/Dean McGee Eye Institute, Oklahoma City, Oklahoma;2. Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Abstract:Neuromyelitis optica (NMO) is an autoimmune astrocytopathy caused by anti-aquaporin 4 antibody. Only two patients with NMO have been reported presenting with hearing disorders to our knowledge. We recently treated a 40-year-old woman with NMO complaining of right hearing loss. Audiometry showed minimal asymmetry, but the auditory brainstem responses (ABR) were severely attenuated on the right. The attenuated ABR and her aural symptoms (hearing loss and fullness) improved after steroid treatment. The present case shows that the retrocochlear-type hearing loss may be associated with NMO.
Keywords:Auditory brainstem response  Multiple sclerosis  Neuromyelitis optica
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