广州市2006—2021年人感染链球菌病流行特征分析

目的 分析广州市人感染猪链球菌病流行病学特征，为有针对性开展人感染猪链球菌病防控工作提供依据。方法 开展流行病学个案调查，采集病例的脑脊液或血液标本进行细菌培养与分离、生化鉴定、血清分型和PCR检测。结果 2006年至2021年，广州市共累计报告75例人感染猪链球菌病例，其中，本地病例46例，输入病例29例。报告了1例死亡病例，病死率为1.33%。以夏秋季多发，占比74.67%，病例年龄分布中位数为58（47，66）岁，患者以男性为主，男女比例为3.17DK]∶1；发病人群的职业分布为来自屠宰场或从事猪肉零售相关工作、离退人员、家务及待业、农民、餐饮食品业、工人；职业和生活接触暴露占56.00%，暴露前手部有伤口病例占28.57%；猪链球菌的血清型以2型为主，占比76.60%。结论 广州市人感染猪链球菌的防控形势较为严峻，需完善联防联控机制，加强与动物防疫部门的交流与协作，提高疾病的监测预警能力。

Surveillance and epidemiological analysis of human streptococcus suis infection in Guangzhou, 2006—2021

Objective To analyze the epidemiological characteristics of human Streptococcus suis infection in Guangzhou, and provide basis for the targeted prevention and control of human-infected Streptococcus suis disease. Methods Epidemiological case investigations were carried out, cerebrospinal fluid or blood samples from cases were collected for bacterial culture and isolation, biochemical identification, serotyping, and PCR testing. Results From 2006 to 2021, a total of 75 cases of human infection with Streptococcus suis were reported in Guangzhou, including 46 local cases and 29 imported cases. One death case was reported, with a case fatality rate of 1.33%. Most cases occurred in summer and autumn, accounting for 74.67%. The median age distribution of the cases was 58 (47, 66) years old. The patients were mainly male, with a male to female ratio of 3.17:1. The occupational distribution of the affected population was from slaughterhouses or engaged in pork retail related work, retirees, housework and unemployed, farmers, catering and food industry, workers, with occupational and daily contact exposure accounting for 56.00%, cases with wounds on the hands before exposure 28.57%. The serotype of Streptococcus suis was mainly type 2, accounting for 76.60%. Conclusion The situation of prevention and control of human infection with Streptococcus suis in Guangzhou is relatively severe. It is necessary to improve the joint prevention and control mechanism, strengthen exchanges and cooperation with animal epidemic prevention departments, and improve disease monitoring and early warning capabilities.